In order to eliminate doubts about the impact of limestone manufactured sand on the deicer-salt resistance of pavement cement concrete, a comparative study was conducted on the influence of limestone manufactured sand with different micro-fines contents on the deicer-salt resistance of pavement cement concrete, using C30 and C50 strength grades as benchmarks. The results showed that the appropriate amount of micro-fines in limestone manufactured sand can improve the mechanical properties and deicer-salt resistance of manufactured sand concrete. When the micro-fines content is 7%~10%, C30 pavement concrete has the best deicer-salt resistance, while C50 pavement cement concrete has the most suitable micro-fines content of 3%~5%. At the same time, the micro-fines content in limestone manufactured sand further confirms the micro aggregate effect of micro-fines on the water saturation and resistance to CaCl2 and NaCl chemical erosion of concrete. With an appropriate amount of stone powder, the compactness of concrete is improved, the degree of water-saturation of cement concrete is reduced, and the deicer-salt resistance of cement concrete is improved.