To recycle the municipal solid waste incineration bottom ash（MSWI-BA）， the effects of different active excitation methods on the 28-day compressive strength of mortar test blocks prepared by pretreated MSWI-BA were studied by the method of response surface central composite test method(RSM-CCD). The results show that the MSWI-BA cementitious material has good cementitious activity by active excitation. The RSM-CCD test simulates that the 28-day compressive strength of the cement mortar test block with 10% MSWI-BA reaches 46.04 MPa under the optimal experimental conditions. Under this condition， the 28-day compressive strength of the cement mortar test block reaches 46.15 MPa， which is highly coincident with the predicted value. This method provides a solution for the resource utilization of MSWI-BA. Finally， the safety of the cementitious material is evaluated. The leaching performance of heavy metals meets the requirements of GB 30760—2014 Technical Specification for Coprocessing of Solid Waste in Cement Kiln.