The mix design of manufactured aggregate was proposed based on the Dinger-Funk grading model. The mass relationship between binder and water for concrete with manufactured aggregate was determined by modifying the Bolomey’s formula. The paste thickness was introduced to establish the volume relationship between aggregate and paste. In addition， the stone powder in manufactured sand was considered as a component of the paste. Finally， the mix design method of concrete with manufactured sand was proposed and verified with concrete of different strength grades. The results show that the workability of concrete can be regulated by the paste thickness. The compressive strength of concrete and the diffusion coefficient of chloride have no obvious correlation with the paste thickness， with the water to binder ratio being the main factor regulating the hardened performance of concrete. The proposed mix design method can be used to quantitatively design concrete with manufactured aggregate for various performance requirements.