In order to determine the appliability of the utilization of limestone manufactured sand in severe cold area， taking the relative dynamic elastic modulus as the evaluation index， the effects of strength， air content and powder content on the frost resistance of limestone manufactured sand concrete were studied， and the reasons of freeze-thaw failure of manufactured sand concrete were analyzed by water absorption and bubble spacing coefficient. The results show that high strength limestone manufactured sand concrete has the characteristics of high frost resistance and sudden failure. Increasing the strength and introducing appropriate amounts of bubbles are effective ways to improve the frost resistance of limestone manufactured sand concrete. The frost resistance is the best when the air content of C30 and C60 manufactured sand concrete is 6.4% and 4.4%， respectively. The limestone powder in manufactured sand has both positive and negative effects on the performance of concrete. The content of limestone powder in manufactured sand is controlled within 10.0%， which is beneficial to frost resistance， mechanical properties and workability.