In order to increase the consumption of shellfish waste and realize the recycling of resources， the mussel coarse aggregate was used to replace the natural coarse aggregate. The mussel coarse aggregate concrete with the substitution rate of 15%， 30%， 45%， 60% and 100% was prepared， and its macro and micro properties were studied. The results show that the mussel coarse aggregate has a high content of inorganic calcium， but as a substitute for natural coarse aggregate， the physical properties of mussel coarse aggregate are weaker than that of natural coarse aggregate because the water absorption is 2.4%， the apparent density is 2 402 kg/m3， and the crushing index is 68.2%， which exceeds the requirements of the specification.With the increase of the replacement rate of mussel coarse aggregate， the mechanical properties of mussel coarse aggregate concrete decrease. The main reason for the deterioration of concrete performance is the defect area in the interface transition zone between mussel coarse aggregate and mortar. The mix design shows that when the replacement rate of mussel coarse aggregate is 30%， the mussel coarse aggregate concrete with C30 strength can be prepared.