The adsorption regularities of typical lithologic manufactured sands to water, methylene blue and polycarboxylate superplasticizer were studied by taking the quartzite, limestone, granite and basalt as research objects. The adsorption characteristics of manufactured sands were analyzed by Zeta potential, adsorption-desorption isotherm and intrusive mercury curve. The results show that the adsorptions of basalt manufactured sand to water and methylene blue were significantly higher than those of other lithologic manufactured sands due to its larger specific surface area and higher porosity. And the adsorption capacity of basalt manufactured sand was increased significantly with the increase of stone powder content. The double electric layer formed by the surface negative charges of stone powder and cations in solution could adsorb superplasticizer molecules. The adsorption ratio of polycarboxylate superplasticizer by stone powders was shown as follows: basalt > limestone > granite > quartzite. With the coupling effect of electric double layer adsorption and physical adsorption, the adsorption ratio of basalt manufactured sand for superplasticizer was significantly higher than those of other lithologic manufactured sands.