Experimental study of eccentric compression of 36steel bamboo combination box columns was carried out by mechanical parameters of the eccentricity, aspect ratio and with or without screw. The destructive pattern, lateral deflection, deformation and bearing capacity of the combination column were analyzed and the main factors affecting mechanical performance under eccentric compression of them were also discussed. There gives a nonlinear whole process program analysis using nonlinear analysis program based on fiber model method. The results show that the damage of the different eccentricity specimens with smaller aspect ratio is caused by the splitting of the bamboo and the buckling of the steel. The damages of the lange aspect ratio specimens are caused by the splitting of bamboo in the middle of the column. Within the design parameters, the eccentricity has a great influence on the mechanical properties of the composite column. The screw reinforcement connection has a certain effect on the yield bearing capacity and ultimate bearing capacity of the specimens. The change of aspect ratio has certain effect but no obvious regularity. The calculation results obtained by the program agree well with the experimental results, their errors are within 10%, which indicates that the established calculation method has high accuracy.