A quadratic polynomial regression equation was established by response surface method to optimize the mix proportion of vinyl chloride，ethylene and ethylene ether ternary polymer mortar. The mechanism was analyzed by combining the macroscopic property and microscopic morphology. The results show that the model can accurately predict the results within the test range, and the response surface method is accurate and scientific in the mix proportion optimization of ternary polymer mortar. The order of influence factors on the 28 d compressive strength is water to cement ratio, water reducer content, polymer content. While that on 28 d flexural strength and bonding strength is polymer content, water to cement ratio and water reducer content. Taking the maximum bonding strength, the maximum flexural strength and the minimum compressive strength (the maximum flexural-compressive strength ratio ) as the target optimization values, it is concluded that the optimal mix proportion of ternary polymer mortar is: polymer content is 12%, water to cement ratio is 0.42 and water reducer content is 1.12%.