The mechanical properties of Q460 high-strength steel specimens were tested under both monotonic and repeated tensile loading. The quantity of holes， the position of holes and the loading patterns were set as the main factors to explore their influence on failure mode， ultimate tensile strength， stress cycling characteristic and energy dissipation capability of specimens. Experimental results show that the opening holes have a significant effect on mechanical properties of Q460 specimen. Specimens with holes present obvious stress concentration phenomenon around the holes. The energy dissipation capacity and elongation of unopened specimens are much greater than those of specimens with holes. Compared with the holes along the long axis of specimen， the holes along the short axis have a more significant effect on mechanical properties of Q460 steel. Furthermore， with the same quantity of openings and opening positions， the strain amplitude of loading pattern has a greater influence on mechanical properties of specimen， and the energy dissipating capacity decreases with the increase of the strain amplitude.