In order to analyze the effects of freeze thaw cycle, salt mass fraction and surfactant type warm mixing agent(SDYK) on fatigue properties of rubber powder modified asphalt mixture, the relationship between number of freeze thaw cycle and bending stiffness modulus was obtained by trabecular four point bending fatigue test, and the fatigue life and energy consumption theory were combined to analyze the relationship. The results show that the fatigue life of asphalt mixture decreases with the increase of freeze thaw times; when the salt mass fraction is 8%, the coupling effect of water frost heaving and salt erosion is the strongest, and the fatigue life is the shortest. When the salt mass fraction is more than 8%, the frost heaving of water will be inhibited. The fatigue performance of asphalt mixture with warm admixture is better.