In order to investigate the impact of pavement texture on uniformity of tire pavement contact stress distribution, the radial tire and different asphalt pavements were chosen as the study object. Through using pressure sensitive film measurement system, the contact stress distribution characteristics between tire and different asphalt pavements were studied. Besides, a mathematical model was also proposed to describe the actual contact stress distribution. The uniformity of tire pavement contact stress distribution and its influencing factors were investigated. According to the results, the contact stress between tire and asphalt pavement is conformed to Weibull distribution on the basis of the P P chart. Weibull modulus can be used to describe the degree of nonuniformity of contact stress distribution. Compared with the influence of load, that of road roughness on the non uniform degree of contact stress distribution is more significant. Although the stress of the outside blocks is notably increased in overloading, the middle blocks stress is not changed much. The roughness of pavement is proved to be the main factor influencing the stress concentration. The peak contact stress and the pavement texture depth fit in a highly significant linear regression equation, thus providing theoretical guidance for designing the asphalt pavement wearing surface.