In order to study the effect of freeze thaw cycles on the compression performance, 24 recycled concrete brick masonry specimens were tested in the laboratory with climate simulation. The changing rule of compressive strength, elastic modulus and the constitutive relation curve along with the increase of the number of freeze thaw cycle was established, and the degradation relationship of the average compressive strength of brick masonry structure with the number of freeze thaw cycle was also established. Based on the fitting of the measured stress strain curve of masonry, the masonry compressive constitutive relation curves with different cycles was obtained, which will provide theoretical basis for active masonry structure durability and seismic performance evaluation under the freeze thaw cycle.