To analyze self healing characteristic of asphalt mixture, variable loading frequencies for synchronous self healing and variable rest period conditions for after loading self healing were conducted through four point bending fatigue test. The results indicate that synchronous self healing is induced by loading, and the ratio of fatigue life(RL) of synchronous self healing for different type of mixture ranges in SBS AC13>TB AC13>Virgin asphalt AC13. Rest period temperature, rest time and extra load have positive influence on after loading self healing while damage ratio has negative influence on after loading self healing. After loading self healing of AR mixture is less influenced by rest period conditions than SBS mixture, also less sensitive to asphalt content than SBS mixture. Stiffness recovery is bigger than fatigue life recovery in evaluating after load self healing while fatigue life recovery is scattered but stiffness recovery is stable.