The 28d compressive strength of compound binder was predicted by simplex centroid experimental design. According to the predicted 28d compressive strength of compound binder and the known water binder ratio, the 28d compressive strength of concrete with admixture was estimated with Bolomy formula. The results show that the 28d compressive strength of compound binder can be predicted relatively correctly by simplex centroid experimental design，and the 28d compressive strength of concrete with admixture can be foreseen relatively correctly by substituting the predicted 28d compressive strength of compound binder and the known water binder ratio into Bolomy formula. The water binder ratio of concrete with admixture can be calculated relatively correctly by substituting the predicted compressive strength of compound binder and the design compressive strength of concrete with admixture into Bolomy formula. So the mix proportion of concrete with admixture can be obtained relatively correctly with absolute volume method. By using this mix proportion design of concrete with admixture, the each composition of compound binder can be regarded as independent component of concrete like water or aggregate.