“Filling in gradation”method has been adopted in the skeleton interlocking dense gradation design with “equi volume replacement”method as the guiding idea for solving the problem of inadequacy of conventional gradation design methodologys direct application in the design of dry process crumb rubber modified asphalt mixture. The research on the mix design system for dry process crumb rubber modified asphalt mixture was carried out adopting the method of replacement of equi volume aggregates with quantified crumb rubbers. The results demonstrate that the gradation has the most predominant effect on the mass loss in Cantabro test compared with the asphalt aggregate ratio, and the crumb rubber content affects least in the three factors. The results indicate that with the skeleton interlocking dense gradation and no more than 50% of the coarse rubber, the asphalt aggregate ratio increased by 0.3% on top of the original gradation, the good performance of the dry process crumb rubber modified asphalt mixture with 5.0% rubber content by the aggregate in volume can be achieved in Cantabro test. In addition, the dynamic stability can be improved distinctly when the rubber content accounts for 3.0% in volume, but then reduced with the continuous increase of rubber content.