The deformation and interior humidity of the concrete specimen under sealed condition were continuously measured for at least 77 d and the simulation of concrete self desiccation and autogenous shrinkage caused by cement hydration was done. The experimental results show that the development of shrinkage and the interior humidity are of high synchronicity. The interior humidity may serve as the driving force parameter for concrete deformation. The lower the water to cement ratio is, the larger the variation of relative humidity caused by self desiccation and concrete shrinkage are. The calculation models of concrete self desiccation and autogenous shrinkage based on the cement hydration degree and interior humidity can well simulate the development of concrete interior humidity and autogenous shrinkage. The results of the model prediction are in agreement with the test data and the calculation models can be used for the prediction of concrete self desiccation and autogenous shrinkage under different curing conditions.