Nowadays, few people investigated the strength and durability of concrete with manufactured sand in severe environment. Experiment studies on C30 concrete with manufactured sand were carried out under condition of high temperature and freeze thaw cycles based on the testing of raw materials performances and concrete mix proportion. Comparative studies on the changing laws of the strength and the relative dynamic elastic modulus of concrete with manufactured sand were made in some cases, including high temperature and freeze thaw cycles, acid corrosion after high temperature and freeze thaw cycles and alkali corrosion following high temperatures and freeze thaw cycles. The results of tests indicate that the strength and the relative dynamic elastic modulus of concrete with manufactured sand decreases markedly with the increase of temperature and the number of freeze thaw cycles. The acid and alkali resistance of concrete with manufactured sand is also remarkably weakened due to the action of heating and freeze thaw cycles. The acid and alkali resistance, especially the acid resistance of the concrete lowers with the increase of temperature and the number of freeze thaw cycles.