Concrete with coal gangue slag to replace natural sand was prepared for the purpose of harmless management, resources utilization and industrialization of coal gangue slag. Experiment results show that the compressive strength of concrete adding proper quantity of coal gangue slag reaches 50MPa, which is higher than the standard concrete. With increasing of coal gangue slag, the slump of the concrete decreases. The durability of concrete adding proper quantity of coal gangue slag is much better than that of normal concrete.