Strength is an important index for the design and construction quality control of cement stabilized macadam meterial. When aggregate type, gradation and forming method are fixed, strength of cement stabilized macadam depends on cement dosage. The higher the standard is, the higher the cement dosage needed is. And then the anti-damage ability of cement stabilized macadam will be greater, but meanwhile, the anti shrinkage cracking ability will get worse, and vice versa. The standard should be determined by the minimum strength needed to avoid the fatigue damage of cement stabilized macadam base under loading. Therefore, taking cement stabilized limestone macadam as object, researches into the mechanical strength characteristics and fatigue property, and also the load response of cement stablilized macadam base during the construction and operation period are conducted, and the cement stabilized macadam stength standard for fatigue fracture controlling is proposed. The researches show that: aiming at preventing the ultimate damage of base course caused by construction vehicle load, the construction of next structure layer should not be conducted until the curing age of cement stabilized limestone macadam is no less than 7d, and the splitting strength is no less than 0.68MPa; aiming at preventing the fatigue damage of base course under repeated load effect of the construction and operation vehicle during the designed usage, the 7d splitting strength should be no less than 0.70MPa. In order to facilitate application, considering the relationship between compressive strength and splitting strength, it is proposed that the 7d compressive strength of cement stabilized limestone macadam should be no less than 7.0 MPa.