The influence of repeated condensation of ice on volume indexes, mechanical properties, high and low temperature performance and water stability of asphalt mixture were analyzed through related experiments. For southern plateau wet pavement, the dense gradation AC16 mixture was adopted in experiments, which was used to be the top layer of local asphalt pavement. The experimental condition was established according to actual condition, and kinds of performance experiments were executed with specimens under different condensation of ice. The results show that the initial void plays major role on the void of mixture during repeated condensation of ice. The high temperature stability of mixture decreases with the increase of repeated condensation of ice. The mechanical properties, water stability, and low temperature properties of mixture have different degree of attenuation after repeated condensation of ice, which decay rapidly at about first 8 cycles, then tends to be stable.