Based on the calculation methods of equivalent water-cement ratio of concrete and average paste thickness of aggregates provided by authors,the nonlinear relation between 28 d concrete compressive strength and equivalent water-cement ratio of concrete,average paste thickness of aggregates,fly ash-binder ratio is established by using artificial neural network.The outcome can be used to reduce the number of trial and error,save cost,labor and time in concrete mix proportion design,and can further lay the foundation for the mix proportion design of high volumestability concrete.