Translucent concrete panel (TCP) is a novel material for building envelope. It combines light conduits such as optical fibers (OFs), and light-weight, high-strength concrete, which enable the TCP to transmit light and load bearing capacity. A series of TCPs were cast with large diameter OFs, compressive strength and thermal conductivity properties were tested. To investigate the energy efficient performance of the TCPs, one-room office building model was built with SketchUp, and EnergyPlusTM software packages. The annual thermal consumption of the building with three types of fa?ades, i.e., masonry, glass curtain wall, and TCP, were computed. Results show that building with TCP fa?ade consumes the lowest electricity, and the corresponding monetary cost is the lowest as well. In addition, the volume ratio of the OF has impact to the overall energy consumption. The novel TCP fa?ade has great priority in the field of building fa?ade system.