Iron tailing sand was used as aggregate to prepare cement based grouting material. Compared with quartz sand grouting material(QG), the properties of iron tailing sand grouting material(ITG) were comprehensively analyzed. The results show that the rheological parameters of ITG are slightly different from QG, e.g. ITG has got slightly higher yield stress, almost the same plastic viscosity and slightly higher thixotropy, so the workability of ITG is slightly lower than that of QG. After hardening,the strength of ITG is slightly lower than that of QG. The porosity of ITG is lower than that of QG, and there are more harmless pores and less harmful pores in ITG. The hardness of iron tailing sand is lower than that of quartz sand, but in ITG, the interfacial transition zone is denser and the microhardness of the interface is slightly higher. It has little effect on the properties of grouting material that iron tailing sand instead of quartz sand as grouting aggregate, and has good technical feasibility.