The four point bending fatigue test was used to analyse the fatigue and self healing properties of two asphalt mixtures under aging condition. The results show that aging weakens anti fatigue performance significantly, and the styrene butadiene styrene tri block copolymer(SBS) modified asphalt mixture has better anti fatigue performance than matrix asphalt mixture. The degree of aging and damage influence the healing ability of asphalt mixture significantly. Prolonging the healing time and healing appropriate temperature can improve the healing rate of asphalt mixture, while aging degree and damage degree can weaken the self healing ability. Under the unaged condition, the matrix asphalt mixture has a better self healing ability than SBS modified asphalt mixture, but under aging condition, the SBS modified asphalt mixture has a better self healing ability, so using SBS modified asphalt mixture as pavement material can improve the anti fatigue and self healing properties of the asphalt pavement.